파르네소이드 X 수용체

파르네소이드 X 수용체(영어: farnesoid X receptor, FXR) 또는 NR1H4(핵 수용체 서브 패밀리 1, 그룹 H, 구성원 4-nuclear receptor subfamily 1, group H, member 4)로도 알려진 담즙산 수용체(BAR,bile acid receptor)는 인간의 NR1H4 유전자에 의해 암호화된 핵 수용체(nuclear receptor)이다.

NR1H4
사용 가능한 구조 PDB 동원체 검색: PDBe RCSB PDB ID 코드 목록 1OSH, 3BEJ, 3DCT, 3DCU, 3FLI, 3FXV, 3GD2, 3HC5, 3HC6, 3L1B, 3OKH, 3OKI, 3OLF, 3OMK, 3OMM, 3OOF, 3OOK, 3RUT, 3RUU, 3RVF, 3P88, 3P89, 4OIV, 4WVD, 4QE6, 4QE8
식별자
다른 이름	NR1H4, BAR, FXR, HRR-1, HRR1, RIP14, nuclear receptor subfamily 1 group H member 4, PFIC5
외부 ID	OMIM: 603826 MGI: 1352464 HomoloGene: 3760 GeneCards: NR1H4
유전자 위치 (인간) 염색체 12번 염색체 자리 12q23.1 시작 100,473,708 bp 끝 100,564,414 bp
유전자 위치 (쥐) 염색체 10번 염색체 (쥐) 자리 10 C2|10 44.98 cM 시작 89,290,096 bp 끝 89,369,447 bp
RNA 발현 패턴 Bgee 인간 쥐(동원체) 최상위 발현 간오른엽 mucosa of ileum right adrenal gland right adrenal cortex oocyte left adrenal gland left adrenal cortex jejunal mucosa 샘창자 secondary oocyte 최상위 발현 right kidney epithelium of small intestine 회장 (해부학) left lobe of liver human kidney 근위 세뇨관 Ileal epithelium Paneth cell 공장 migratory enteric neural crest cell 추가 참조 발현 데이터 BioGPS 추가 참조 발현 데이터
유전자 온톨로지 분자 함수 RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding DNA 결합 transcription corepressor activity DNA-binding transcription factor activity transcription coactivator activity zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific 금속 이온 결합 retinoid X receptor binding steroid hormone receptor activity bile acid binding 단백질 결합 nuclear receptor binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding chenodeoxycholic acid binding transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding nuclear receptor activity bile acid receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor binding nuclear receptor coactivator activity signaling receptor activity 세포 성분 핵질 세포핵 RNA polymerase II transcription regulator complex 생물학적 과정 Notch signaling pathway cellular triglyceride homeostasis cellular response to organonitrogen compound regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of ammonia assimilation cycle toll-like receptor 4 signaling pathway 면역 과정 histone H3-R17 methylation regulation of transcription by RNA polymerase II positive regulation of glutamate metabolic process intracellular bile acid receptor signaling pathway 세포자멸사 과정의 하향조절 negative regulation of transcription by RNA polymerase II DNA를 주형으로 한 전사 regulation of low-density lipoprotein particle clearance regulation of bile acid biosynthetic process regulation of cholesterol metabolic process regulation of urea metabolic process intracellular receptor signaling pathway negative regulation of bile acid biosynthetic process cellular response to fatty acid bile acid and bile salt transport nitrogen catabolite activation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter inflammatory response 선천면역 신호전달 steroid hormone mediated signaling pathway fatty acid homeostasis positive regulation of insulin receptor signaling pathway cellular response to lipopolysaccharide negative regulation of interleukin-2 production positive regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of inflammatory response glucose homeostasis negative regulation of NF-kappaB transcription factor activity positive regulation of adipose tissue development cell-cell junction assembly toll-like receptor 9 signaling pathway negative regulation of monocyte chemotactic protein-1 production bile acid metabolic process negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of tumor necrosis factor-mediated signaling pathway 세균에 대한 방어 반응 negative regulation of interleukin-1 production negative regulation of tumor necrosis factor production negative regulation of interleukin-6 production triglyceride homeostasis negative regulation of interferon-gamma production DNA를 주형으로 한 전사의 조절 bile acid signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of phosphatidic acid biosynthetic process cholesterol homeostasis 지질 대사 multicellular organism development 세포 분화 lipid homeostasis cellular glucose homeostasis 출처: Amigo / QuickGO
동원체 종 인간 쥐 앙트레 9971 20186 앙상블 ENSG00000012504 ENSMUSG00000047638 유니프롯 Q96RI1 Q60641 RefSeq (mRNA) NM_001206977 NM_001206978 NM_001206979 NM_001206992 NM_001206993 NM_005123 NM_001163504 NM_001163700 NM_009108 NM_001385711 RefSeq(단백질) NP_001193906 NP_001193907 NP_001193908 NP_001193921 NP_001193922 NP_005114 NP_001193906.1 NP_001193908.1 NP_001156976 NP_001157172 NP_033134 NP_001372640 위치(UCSC) Chr 12: 100.47 – 100.56 Mb Chr 10: 89.29 – 89.37 Mb PubMed 검색
위키데이터
인간 보기/편집 쥐 보기/편집

같이 보기

• TGR5